| Player | Altoona Year(s) | MLB Debut | Team |
|---|---|---|---|
| 1. Yamid Haad, C | 1999-01 | 7/5/1999 | Pittsburgh |
| 2. Kory DeHaan, OF | 1999 | 4/25/2000 | San Diego |
| 3. Brian O'Connor, LHP | 1999-00, '02 | 5/13/2000 | Pittsburgh |
| 4. Bronson Arroyo, RHP | 1999 | 6/12/2000 | Pittsburgh |
| 5. Kane Davis, RHP | 1999 | 6/12/2000 | Cleveland |
| 6. Tike Redman, OF | 1999 | 6/30/2000 | Pittsburgh |
| 7. Stephen L. Sparks, RHP | 2000-01 | 7/19/2000 | Pittsburgh |
| 8. Alex Hernandez, OF | 1999-00 | 9/1/2000 | Pittsburgh |
| 9. Adam Hyzdu, OF | 1999-00 | 9/8/2000 | Pittsburgh |
| 10. Brian Smith, RHP | 1999-01 | 9/11/2000 | Pittsburgh |
| 11. Jack Wilson, SS | 2000, 2008 | 4/3/2001 | Pittsburgh |
| 12. Joe Beimel, LHP | 2000, 2011 | 4/8/2001 | Pittsburgh |
| 13. Craig Wilson, C/1B | 1999 | 4/22/2001 | Pittsburgh |
| 14. Rob Mackowiak, UTL | 1999-00 | 5/19/2001 | Pittsburgh |
| 15. Dave Williams, LHP | 2001 | 6/6/2001 | Pittsburgh |
| 16. Jarrod Patterson, 3B | 2000 | 6/16/2001 | Detroit |
| 17. Luis Figueroa, INF | 1999-00 | 6/27/2001 | Pittsburgh |
| 18. Humberto Cota, C | 2000 | 9/9/2001 | Pittsburgh |
| 19. Brendan Donnelly, RHP | 1999 | 4/9/2002 | Los Angeles (AL) |
| 20. Ron Wright, 1B | 1999 | 4/14/2002 | Seattle |
| 21. Kevin Pickford, LHP | 2000 | 5/16/2002 | San Diego |
| 22. Matt Duff, RHP | 1999-00 | 7/30/2002 | St. Louis |
| 23. Tony Alvarez, OF | 2001-02 | 9/4/2002 | Pittsburgh |
| 24. J.J. Davis, OF | 2001-02 | 9/4/2002 | Pittsburgh |
| 25. Chris Spurling, RHP | 2001-02 | 4/2/2003 | Detroit |
| 26. D.J. Carrasco, RHP | 2000-01 | 4/2/2003 | Kansas City |
| 27. Carlos Rivera, 1B | 2001-02 | 6/22/2003 | Pittsburgh |
| 28. Mike Gonzalez, LHP | 1999, 01-03 | 8/11/2003 | Pittsburgh |
| 29. John Grabow, LHP | 2000-03 | 9/14/2003 | Pittsburgh |
| 30. J.R. House, C | 2001-03 | 9/27/2003 | Pittsburgh |
| 31. Shawn Camp, RHP | 2001, '03 | 4/5/2004 | Kansas City |
| 32. Jeff Bennett, RHP | 2001, '03 | 4/6/2004 | Milwaukee |
| 33. Jose Castillo, INF | 2003 | 4/7/2004 | Pittsburgh |
| 34. Mike Johnston, LHP | 2003 | 4/7/2004 | Pittsburgh |
| 35. Chris Shelton, 1B/C | 2003 | 4/15/2004 | Detroit |
| 36. Anastacio Martinez, RHP | 2003 | 5/22/2004 | Boston |
| 37. Sean Burnett, LHP | 2003 | 5/30/2004 | Pittsburgh |
| 38. Sam McConnell, LHP | 1999-00 | 6/25/2004 | Atlanta |
| 39. John Van Benschoten, RHP | 2003, '06 | 8/18/2004 | Pittsburgh |
| 40. Ian Snell, RHP | 2003-04 | 8/20/2004 | Pittsburgh |
| 41. Jeff Keppinger, INF | 2004 | 8/20/2004 | New York (NL) |
| 42. Frank Brooks, LHP | 2003 | 8/27/2004 | Pittsburgh |
| 43. Chris Duffy, OF | 2003-04, '08 | 4/7/2005 | Pittsburgh |
| 44. Ray Sadler, OF | 2003-06 | 5/8/2005 | Pittsburgh |
| 45. Ryan Doumit, C | 2001, '04, '06, '08 | 6/5/2005 | Pittsburgh |
| 46. Nate McLouth, OF | 2004 | 6/29/2005 | Pittsburgh |
| 47. Zach Duke, LHP | 2004, '10 | 7/2/2005 | Pittsburgh |
| 48. Brad Eldred, 1B | 2004-05 | 7/22/2005 | Pittsburgh |
| 49. Paul Maholm, LHP | 2005 | 8/30/2005 | Pittsburgh |
| 50. Chris Heintz, C | 2003 | 9/10/2005 | Minnesota |
| 51. Matt Capps, RHP | 2005, '08 | 9/16/2005 | Pittsburgh |
| 52. Bryan Bullington, RHP | 2004 | 9/18/2005 | Pittsburgh |
| 53. Tom Gorzelanny, LHP | 2004-05 | 9/20/2005 | Pittsburgh |
| 54. Ronny Paulino, C | 2003-05 | 9/25/2005 | Pittsburgh |
| 55. Yurendell de Caster, INF | 2004 | 5/21/2006 | Pittsburgh |
| 56. Josh Sharpless, RHP | 2005-06 | 8/1/2006 | Pittsburgh |
| 57. Rajai Davis, OF | 2005 | 8/14/2006 | Pittsburgh |
| 58. Brian Rogers, RHP | 2006, '08 | 9/1/2006 | Pittsburgh |
| 59. Carlos Maldonado, C | 2005-07 | 9/8/2006 | Pittsburgh |
| 60. Shane Youman, LHP | 2004-06 | 9/10/2006 | Pittsburgh |
| 61. Craig Stansberry, INF | 2005-06 | 8/25/2007 | San Diego |
| 62. Romulo Sanchez, RHP | 2005-07 | 8/26/2007 | Pittsburgh |
| 63. Steve Pearce, 1B | 2007 | 9/1/2007 | Pittsburgh |
| 64. Nyjer Morgan, OF | 2006 | 9/1/2007 | Pittsburgh |
| 65. Jonathan Albaladejo, RHP | 2006 | 9/5/2007 | Washington |
| 66. Dave Davidson, LHP | 2006-08 | 9/6/2007 | Pittsburgh |
| 67. Rico Washington, INF | 2000-02 | 4/1/2008 | St. Louis |
| 68. Brian Bixler, INF | 2006 | 4/6/2008 | Pittsburgh |
| 69. Brent Lillibridge, INF | 2006 | 4/26/2008 | Atlanta |
| 70. Jimmy Barthmaier, RHP | 2008, '10 | 6/27/2008 | Pittsburgh |
| 71. Yoslan Herrera, RHP | 2007-09 | 7/12/2008 | Pittsburgh |
| 72. Randy Ruiz, 1B | 2007 | 8/1/2008 | Minnesota |
| 73. Luis Cruz, INF | 2008 | 9/2/2008 | Pittsburgh |
| 74. Ronald Belisario, RHP | 2007-08 | 4/7/2009 | Los Angeles (NL) |
| 75. Andrew McCutchen, OF | 2006-07 | 6/4/2009 | Pittsburgh |
| 76. Neil Walker, INF | 2006-07, '13 | 9/1/2009 | Pittsburgh |
| 77. Jose Tabata, OF | 2008-09 | 6/9/2010 | Pittsburgh |
| 78. Brad Lincoln, RHP | 2009 | 6/9/2010 | Pittsburgh |
| 79. Pedro Alvarez, 3B | 2009 | 6/16/2010 | Pittsburgh |
| 80. Alex Presley, OF | 2010 | 9/8/2010 | Pittsburgh |
| 81. Mike Crotta, RHP | 2007, '09-11 | 4/3/2011 | Pittsburgh |
| 82. Daniel Moskos, LHP | 2009-10 | 4/30/2011 | Pittsburgh |
| 83. Josh Harrison, 2B/3B | 2010, '18 | 5/31/2011 | Pittsburgh |
| 84. Tony Watson, LHP | 2009-10 | 6/8/2011 | Pittsburgh |
| 85. Chase d'Arnaud, 2B/SS | 2010, '13 | 6/24/2011 | Pittsburgh |
| 86. Eric Fryer, C | 2011 | 6/26/2011 | Pittsburgh |
| 87. Aaron Thompson, LHP | 2011 | 8/24/2011 | Pittsburgh |
| 88. Jared Hughes, RHP | 2008-11, '13 | 9/7/2011 | Pittsburgh |
| 89. Jeff Locke, LHP | 2010-11 | 9/10/2011 | Pittsburgh |
| 90. Matt Hague, 1B | 2010 | 4/7/2012 | Pittsburgh |
| 91. Gorkys Hernandez, OF | 2009-10 | 5/21/2012 | Pittsburgh |
| 92. Jordy Mercer, INF | 2010-11 | 5/29/2012 | Pittsburgh |
| 93. Starling Marte, OF | 2011 | 7/26/2012 | Pittsburgh |
| 94. Todd Redmond, RHP | 2007 | 8/18/2012 | Cincinnati |
| 95. Kyle McPherson, RHP | 2011-12 | 8/20/2012 | Pittsburgh |
| 96. Justin WIlson, LHP | 2010 | 8/20/2012 | Pittsburgh |
| 97. Steve Lerud, C | 2008-09 | 8/30/2012 | Philadelphia |
| 98. Brock Holt, 2B/SS | 2011-12 | 9/1/2012 | Pittsburgh |
| 99. Jean Machi, RHP | 2009 | 9/3/2012 | San Francisco |
| 100. Bryan Morris, RHP | 2010-11 | 9/14/2012 | Pittsburgh |
| 101. Phil Irwin, RHP | 2011-12 | 4/14/2013 | Pittsburgh |
| 102. Robbie Grossman, OF | 2012 | 4/24/2013 | Houston |
| 103. Gerrit Cole, RHP | 2012 | 6/11/2013 | Pittsburgh |
| 104. Brandon Cumpton, RHP | 2012-13, '17 | 6/15/2013 | Pittsburgh |
| 105. Tony Sanchez, C | 2011-13 | 6/23/2013 | Pittsburgh |
| 106. Duke Welker, RHP | 2011-12 | 6/23/2013 | Pittsburgh |
| 107. Vic Black, RHP | 2012 | 7/25/2013 | Pittsburgh |
| 108. Andrew Lambo, OF | 2010-13 | 8/13/2013 | Pittsburgh |
| 109. Kris Johnson, LHP | 2012 | 8/18/2013 | Pittsburgh |
| 110. Stolmy Pimentel, RHP | 2013-14 | 9/4/2013 | Pittsburgh |
| 111. Casey Sadler, RHP | 2013, '17 | 5/2/2014 | Pittsburgh |
| 112. Rudy Owens, LHP | 2010 | 5/23/2014 | Houston |
| 113. Jamie Romak, INF | 2008-09 | 5/28/2014 | Los Angeles (NL) |
| 114. Gregory Polanco, OF | 2013 | 6/10/2014 | Pittsburgh |
| 115. Hunter Strickland, RHP | 2012 | 9/1/2014 | San Francisco |
| 116. John Holdzkom, RHP | 2014 | 9/2/2014 | Pittsburgh |
| 117. Diego Moreno, RHP | 2010-11 | 6/22/2015 | New York (AL) |
| 118. Alex Dickerson, OF | 2013 | 8/6/2015 | San Diego |
| 119. Ramon Cabrera, C | 2012, '14 | 9/5/2015 | Cincinnati |
| 120. Elias Diaz, C | 2014, '16 | 9/12/2015 | Pittsburgh |
| 121. Keon Broxton, OF | 2014-15 | 9/21/2015 | Pittsburgh |
| 122. Yhonathan Barrios, RHP | 2015 | 9/24/2015 | Milwaukee |
| 123. Alen Hanson, INF | 2013-14 | 5/16/2016 | Pittsburgh |
| 124. A.J. Morris, RHP | 2014 | 5/24/2016 | Cincinnati |
| 125. Jameson Taillon, RHP | 2012-13, '17 | 6/8/2016 | Pittsburgh |
| 126. Adrian Sampson, RHP | 2014 | 6/18/2016 | Seattle |
| 127. Jacob Stallings, C | 2012, '15 | 6/19/2016 | Pittsburgh |
| 128. Adam Frazier, UTL | 2015 | 6/24/2016 | Pittsburgh |
| 129. Chad Kuhl, RHP | 2015 | 6/26/2016 | Pittsburgh |
| 130. Dustin Molleken, RHP | 2009-10 | 7/4/2016 | Detroit |
| 131. Steven Brault, LHP | 2015 | 7/5/2016 | Pittsburgh |
| 132. Tyler Glasnow, RHP | 2015-16 | 7/7/2016 | Pittsburgh |
| 133. Josh Bell, 1B/RF | 2014-15 | 7/8/2016 | Pittsburgh |
| 134. Max Moroff, 2B | 2015 | 7/31/2016 | Pittsburgh |
| 135. JaCoby Jones, SS/OF | 2015 | 8/30/2016 | Detroit |
| 136. Joely Rodriguez, LHP | 2014 | 9/11/2016 | Philadelphia |
| 137. Willy Garcia, OF | 2014-15 | 4/14/2017 | Chicago (AL) |
| 138. Jose Osuna, 1B/OF | 2015-16 | 4/18/2017 | Pittsburgh |
| 139. Dovydas Neverauskas, RHP | 2016 | 4/24/2017 | Pittsburgh |
| 140. Gift Ngoepe, INF | 2013-15, '19 | 4/26/2017 | Pittsburgh |
| 141. Edgar Santana, RHP | 2016 | 6/10/2017 | Pittsburgh |
| 142. Jordan Luplow, OF | 2017 | 7/28/2017 | Pittsburgh |
| 143. Angel Sanchez, RHP | 2014-15 | 8/24/2017 | Pittsburgh |
| 144. Clay Holmes, RHP | 2016, '19 | 4/6/2018 | Pittsburgh |
| 145. Nick Kingham, RHP | 2013-14, '16, '18 | 4/29/2018 | Pittsburgh |
| 146. Brandon Mann, LHP | 2014 | 5/13/2018 | Texas |
| 147. Austin Meadows, OF | 2015-16 | 5/18/2018 | Pittsburgh |
| 148. Robert Stock, RHP | 2015 | 6/24/2018 | San Diego |
| 149. Tanner Anderson, RHP | 2017 | 7/2/2018 | Pittsburgh |
| 150. Jeremy Bleich, LHP | 2015 | 7/13/2018 | Oakland |
| 151. Alex McRae, RHP | 2016-17 | 8/1/2018 | Pittsburgh |
| 152. Kevin Newman, SS | 2016-17 | 8/16/2018 | Pittsburgh |
| 153. Daniel Zamora, LHP | 2017 | 8/17/2018 | New York (NL) |
| 154. Pablo Reyes, UTL | 2017-18 | 9/2/2018 | Pittsburgh |
| 155. Kevin Kramer, 2B | 2017 | 9/5/2018 | Pittsburgh |
| 156. Reese McGuire, C | 2016 | 9/6/2018 | Toronto |
| 157. Nick Burdi, RHP | 2018 | 9/11/2018 | Pittsburgh |
| 158. Connor Joe, OF | 2017 | 3/28/2019 | San Francisco |
| 159. Jason Martin, OF | 2018 | 4/6/2019 | Pittsburgh |
| 160. Cole Tucker, SS | 2017-18 | 4/20/2019 | Pittsburgh |
| 161. Bryan Reynolds, OF | 2018 | 4/20/2019 | Pittsburgh |
| 162. Taylor Hearn, LHP | 2018 | 4/25/2019 | Texas |
| 163. Montana DuRapau, RHP | 2015-18 | 5/9/2019 | Pittsburgh |
| 164. Harold Ramirez, OF | 2016 | 5/11/2019 | Miami |
| 165. Geoff Hartlieb, RHP | 2018 | 5/18/2019 | Pittsburgh |
| 166. Josh Smith, LHP | 2015-16 | 5/25/2019 | Cleveland |
| 167. Mitch Keller, RHP | 2017-18 | 5/27/2019 | Pittsburgh |
| 168. Dario Agrazal, RHP | 2017-19 | 6/15/2019 | Pittsburgh |
| 169. Luis Escobar, RHP | 2018 | 7/13/2019 | Pittsburgh |
| 170. James Marvel, RHP | 2018-19 | 9/8/2019 | Pittsburgh |
| 171. JT Brubaker, RHP | 2017-18 | 7/26/2020 | Pittsburgh |
| 172. Cody Ponce, RHP | 2019 | 8/2/2020 | Pittsburgh |
| 173. Nick Mears, RHP | 2019 | 8/8/2020 | Pittsburgh |
| 174. Brandon Waddell, LHP | 2016-19 | 8/14/2020 | Pittsburgh |
| 175. Will Craig, 1B | 2018 | 8/27/2020 | Pittsburgh |
| 176. Ke'Bryan Hayes, 3B | 2018 | 9/1/2020 | Pittsburgh |
| 177. Wyatt Mathisen, INF | 2017-18 | 9/7/2020 | Arizona |
| 178. Blake Cederlind, RHP | 2019 | 9/15/2020 | Pittsburgh |
| 179. Jared Oliva, OF | 2019 | 9/21/2020 | Pittsburgh |
| 180. Jake Brentz, LHP | 2017-19 | 4/4/2021 | Kansas City |
| 181. Hunter Owen, INF | 2019 | 5/5/2021 | Pittsburgh |
| 182. Max Kranick, RHP | 2021 | 6/27/2021 | Pittsburgh |
| 183. Roansy Contreras, RHP | 2021 | 9/29/2021 | Pittsburgh |
| 184. Oneil Cruz, INF | 2019, 2021 | 10/2/2021 | Pittsburgh |
| 185. Diego Castillo, INF | 2021 | 4/7/2022 | Pittsburgh |
| 186. Beau Sulser, RHP | 2019, '23 | 4/26/2022 | Pittsburgh |
| 187. Jack Suwinski, OF | 2021-22 | 4/26/2022 | Pittsburgh |
| 188. Cam Alldred, LHP | 2021 | 5/12/2022 | Pittsburgh |
| 189. Cal Mitchell, OF | 2021 | 5/24/2022 | Pittsburgh |
| 190. Yerry De Los Santos, RHP | 2021 | 5/25/2022 | Pittsburgh |
| 191. Canaan Smith-Njigba, OF | 2021 | 6/14/2022 | Pittsburgh |
| 192. Jason Delay, C | 2019-22 | 6/14/2022 | Pittsburgh |
| 193. Cam Vieaux, LHP | 2018-21 | 6/17/2022 | Pittsburgh |
| 194. Liover Peguero, INF | 2022-23 | 6/18/2022 | Pittsburgh |
| 195. Bligh Madris, OF | 2019-21 | 6/20/2022 | Pittsburgh |
| 196. Luis Ortiz, RHP | 2022 | 9/13/2022 | Pittsburgh |
| 197. Ji-Hwan Bae, INF/OF | 2021 | 9/23/2022 | Pittsburgh |
| 198. Blake Sabol, C/OF | 2022 | 3/30/2023 | San Francisco |
| 199. Drew Maggi, INF | 2012-14, 2023 | 4/26/2023 | Pittsburgh |
| 200. Cody Bolton, RHP | 2019 | 4/29/2023 | Pittsburgh |
| 201. Joe Jacques, LHP | 2019, 2022 | 6/12/2023 | Boston |
| 202. Osvaldo Bido, RHP | 2021 | 6/14/2023 | Pittsburgh |
| 203. Carmen Mlodzinski, RHP | 2022 | 6/16/2023 | Pittsburgh |
| 204. Henry Davis, C/OF | 2022-23 | 6/19/2023 | Pittsburgh |
| 205. Connor Kaiser, INF | 2021 | 6/19/2023 | Colorado |
| 206. Nick Gonzales, INF | 2022 | 6/23/2023 | Pittsburgh |
| 207. Jared Triolo, INF | 2022 | 6/28/2023 | Pittsburgh |
| 208. Quinn Priester, RHP | 2022 | 7/17/2023 | Pittsburgh |
| 209. Endy Rodriguez, C | 2022 | 7/17/2023 | Pittsburgh |
| 210. Colin Selby, RHP | 2022 | 8/9/2023 | Pittsburgh |
| 211. Hunter Stratton, RHP | 2021 | 9/5/2023 | Pittsburgh |
| 212. Kyle Nicolas, RHP | 2022-23 | 9/19/2023 | Pittsburgh |
| 213. Jared Jones, RHP | 2023 | 3/30/2024 | Pittsburgh |
| 214. Paul Skenes, RHP | 2023 | 5/11/2024 | Pittsburgh |
| 215. Grant Koch, C | 2021-22 | 5/29/2024 | Pittsburgh |
| 216. Luis Peralta, LHP | 2024 | 8/24/2024 | Colorado |
| 217. Mike Burrows, RHP | 2022 | 9/28/2024 | Pittsburgh |
| 218. Thomas Harrington, RHP | 2024 | 4/1/2025 | Pittsburgh |
| 219. Omar Cruz, LHP | 2021-23 | 4/1/2025 | San Diego |
| 220. Tsung-Che Cheng, INF | 2023-24 | 4/9/2025 | Pittsburgh |
| 221. Matt Gorski, OF | 2022-23 | 4/24/2025 | Pittsburgh |
| 222. Braxton Ashcraft, RHP | 2023-24 | 5/26/2025 | Pittsburgh |
| 223. Cam Sanders, RHP | 2025 | 8/5/2025 | Pittsburgh |
| 224. Bubba Chandler, RHP | 2023-24 | 8/22/2025 | Pittsburgh |
| 225. Hunter Barco, LHP | 2024-25 | 9/23/2025 | Pittsburgh |
| Player | Altoona Year(s) | Previous MLB Clubs |
|---|---|---|
| 1. Steve Bieser, C | 1999 | New York (NL), Pittsburgh |
| 2. Enrique Burgos, RHP | 1999 | Kansas City, San Francisco |
| 3. Matt Dunbar, LHP | 1999 | Florida |
| 4. Todd Dunn, OF | 1999 | Milwaukee |
| 5. Joey Long, LHP | 1999 | San Diego |
| 6. Mike Robertson, 1B/OF | 1999 | Chicago (AL), Philadelphia, Arizona |
| 7. Mel Rosario, C | 1999 | Baltimore |
| 8. John Wehner, INF | 1999, '01 | Pittsburgh, Florida |
| 9. Jimmy Anderson, LHP | 2000 | Pittsburgh |
| 10. Keith Williams, OF | 2000 | San Francisco |
| 11. Mike Garcia, RHP | 2001 | Pittsburgh |
| 12. Scarborough Green, OF | 2001 | St. Louis, Texas |
| 13. Shane Monahan, OF | 2001 | Seattle |
| 14. Chris Peterson, INF | 2001 | Colorado |
| 15. Jason Phillips, RHP | 2001 | Pittsburgh |
| 16. Jim Dougherty, RHP | 2002 | Houston, Oakland, Pittsburgh |
| 17. Brian Looney, LHP | 2002 | Montreal, Boston |
| 18. Kevin Sefcik, INF | 2002 | Philadelphia, Colorado |
| 19. Ryan Vogelsong, RHP | 2002 | San Francisco, Pittsburgh |
| 20. Tom Fordham, LHP | 2003 | Chicago (AL) |
| 21. Chan Perry, INF | 2003 | Cleveland, Kansas City |
| 22. Kevin Nicholson, INF | 2003-04 | San Diego |
| 23. Mike Crudale, RHP | 2004 | St. Louis, Milwaukee |
| 24. Tomas de la Rosa, INF | 2004 | Montreal |
| 25. Andrew Lorraine, LHP | 2004 | California, Chicago (AL), Oakland, Seattle, Chicago (NL), Cleveland, Milwaukee |
| 26. David Lundquist, RHP | 2004 | Chicago (AL), San Diego |
| 27. Donaldo Mendez, SS | 2004 | San Diego |
| 28. Mike Moriarty, INF | 2004 | Baltimore |
| 29. Scott Sheldon, INF | 2004 | Oakland, Texas |
| 30. Blake Stein, RHP | 2004 | Oakland, Kansas City |
| 31. Tom Evans, INF | 2004-05 | Toronto, Texas |
| 32. Jose Bautista, 3B | 2005 | Baltimore, Tampa Bay, Kansas City, Pittsburgh |
| 33. Howie Clark, OF | 2005 | Baltimore, Toronto |
| 34. Hansel Izquierdo, RHP | 2005 | Florida |
| 35. Justin Kaye, RHP | 2005 | Seattle |
| 36. Jason Roach, RHP | 2005-07 | New York (NL) |
| 37. Rich Thompson, OF | 2005-06 | Kansas City, Tampa Bay |
| 38. Travis Chapman, OF | 2006 | Philadelphia |
| 39. Brandon Knight, RHP | 2006 | New York (AL) |
| 40. Blaine Neal, RHP | 2006 | Florida, San Diego, Boston, Colorado |
| 41. Simon Pond, OF | 2006 | Toronto |
| 42. Nerio Rodriguez, RHP | 2006 | Baltimore, Toronto, Cleveland, St. Louis |
| 43. Jorge Vasquez, RHP | 2006 | Kansas City, Atlanta |
| 44. Peter Bergeron, OF | 2007 | Montreal |
| 45. Dewon Brazelton, RHP | 2007 | Tampa Bay, San Diego |
| 46. Russ Johnson, INF | 2007 | Houston, Tampa Bay, New York (AL) |
| 47. Jose Paniagua, RHP | 2007 | Montreal, Seattle, Detroit, Chicago (AL) |
| 48. Alay Soler, RHP | 2007 | New York (NL) |
| 49. Chris Truby, INF | 2007 | Houston, Detroit, Montreal, Tampa Bay |
| 50. Melvin Dorta, INF | 2008 | Washington |
| 51. Dan Reichert, RHP | 2008 | Kansas City, Toronto |
| 52. Miguel Perez, C | 2008-09, '12-13 | Cincinnati |
| 53. Juan Mateo, RHP | 2008-09 | Chicago (NL) |
| 54. Evan Meek, RHP | 2008 | Pittsburgh |
| 55. Pedro Lopez, INF | 2009 | Chicago (AL), Cincinnati |
| 56. Anderson Machado, SS | 2009 | Philadelphia, Cincinnati, Colorado |
| 57. Hector Gimenez, UTL | 2009-10 | Houston, Los Angeles (NL), Chicago (AL) |
| 58. Craig Hansen, RHP | 2010 | Boston, Pittsburgh |
| 59. Brandon Jones, OF | 2010 | Atlanta |
| 60. Anthony Clagget, RHP | 2010-11 | New York (AL), Pittsburgh |
| 61. Chris Leroux, RHP | 2011 | Florida, Pittsburgh |
| 62. Josh Rodriguez, INF | 2011 | Pittsburgh |
| 63. Brett Sinkbeil, RHP | 2011 | Florida |
| 64. Donnie Veal, LHP | 2011 | Pittsburgh |
| 65. Logan Kensing, RHP | 2012 | Florida, Washington |
| 66. Shairon Martis, RHP | 2012 | Washington |
| 67. Aaron Poreda, LHP | 2012 | Chicago (AL), San Diego |
| 68. Jose Contreras, RHP | 2013 | New York (AL), Chicago (AL), Colorado, Philadelphia, Pittsburgh |
| 69. Ali Solis, C | 2013 | San Diego |
| 70. Collin Balester, RHP | 2014-2015 | Washington, Detroit |
| 71. Johnny Hellweg, RHP | 2017 | Milwaukee |
| 72. Jackson Williams, C | 2017-18 | Colorado, San Francisco |
| 73. John Bormann, C | 2018 | Pittsburgh |
| 74. Vicente Campos, RHP | 2019 | Arizona |
| 75. Tom Koehler, RHP | 2019 | Miami, Toronto |
| 76. Darnell Sweeney, UTL | 2019 | Philadelphia, Toronto |
| 77. Rodolfo Castro, INF | 2021 | Pittsburgh |
| 78. Tucupita Marcano, INF/OF | 2022 | San Diego |
| 79. Luis Oviedo, RHP | 2022 | Pittsburgh |
| 80. Domingo Leyba, INF | 2023 | Arizona, Baltimore |
| 81. Josh Palacios, OF | 2023 | Toronto, Washington |
| 82. Juan Minaya, RHP | 2023 | Chicago (AL), Minnesota |
| 83. Jackson Wolf, LHP | 2023 | San Diego |
| 84. Joe Perez, INF/OF | 2023-24 | Houston |
| 85. Seth Beer, INF | 2024 | Arizona |
| 86. Isaac Mattson, RHP | 2024 | Baltimore |
| 87. Dustin Peterson, OF | 2024 | Atlanta, Detroit |
| 88. Beau Burrows, RHP | 2025 | Detroit, Minnesota |
Players that played for the Altoona Curve on a Major League Rehab Assignment from the Pittsburgh Pirates. (*Denotes Curve alum)
A complete guide of players to suit up for the Curve and a Major League franchise, listed alphabetically by team. Years of MLB service with each club is noted in parenthesis.
Atlanta Braves (30)
Jose Bautista (2018)
Jeff Bennett (2007-09)
Frank Brooks (2005)
Francisco Cervelli (2019)
Brad Clontz (1995-97)
Juan Cruz (2004)
Chase d'Arnaud (2016-17)
Alex Dickerson (2022)
Ryan Doumit (2014)
Mike Gonzalez (2007-09)
Jason Grilli (2015-16)
Robbie Grossman (2022)
Taylor Hearn (2023)
Brandon Jones (2007-09)
Brett Lillibridge (2008)
Paul Maholm (2012-13)
Sam McConnell (2004)
Nate McLouth (2009-11)
Charlie Morton (2008, 2021-25)
Terry Mulholland (1999-00)
Dustin Peterson (2018)
Tony Sanchez (2017)
Edgar Santana (2021)
Jason Schmidt (1995-96)
Chris Stewart (2018)
Hunter Stratton (2025)
Jorge Vasquez (2005)
Donnie Veal (2015)
Craig Wilson (2007)
Jack Wilson (2011-12)
Arizona Diamondbacks (22)
Jonathan Albaladejo (2012)
Bronson Arroyo (2014)
Seth Beer (2021-22)
Josh Bell (2024)
Kris Benson (2010)
Vicente Campos (2016)
DJ Carrasco (2010)
Diego Castillo (2023)
Juan Cruz (2006-08)
Zach Duke (2011)
Joe Jacques (2024)
Connor Kaiser (2025)
Domingo Leyba (2019, 21)
Jordan Luplow (2022)
Starling Marte (2020)
Wyatt Mathisen (2020-21)
Terry Mulholland (2006)
Kevin Newman (2024)
Mike Robertson (1998)
Jamie Romak (2015)
Chris Stewart (2018)
Turner Ward (1999-2000)
Chicago Cubs (19)
Jimmy Anderson (2004)
Steven Brault (2022)
Nick Burdi (2023)
Shawn Camp (2012-13)
Juan Cruz (2001-03)
Tom Gorzelanny (2009-10)
John Grabow (2009-11)
Brett Lillibridge (2013)
Andrew Lorraine (1999-2000)
Paul Maholm (2012)
Juan Mateo (2006)
Reese McGuire (2025)
Terry Mulholland (1997-99)
Casey Sadler (2020)
Adrian Sampson (2021-2022)
Robert Stock (2021)
Jameson Taillon (2023-25)
Duane Underwood Jr. (2018-20)
Justin Wilson (2017-18)
Cincinnati Reds (23)
Jimmy Anderson (2003)
Bronson Arroyo (2006-13 & 2017)
Collin Balester (2015)
Ramon Cabrera (2015-16)
Sean Casey (1998-2005)
Zach Duke (2013 & 2019)
Phil Dumatrait (2007)
Ke'Bryan Hayes (2025)
Jared Hughes (2018-19)
Connor Joe (2025)
Jeff Keppinger (2007-08)
Pedro Lopez (2007)
Anderson Machado (2004-05)
AJ Morris (2016)
Kevin Newman (2023)
Ross Ohlendorf (2016)
Miguel Perez (2005)
Todd Redmond (2012)
Jose Silva (2002)
Hunter Strickland (2022)
Kip Wells (2009)
David Williams (2006)
Justin Wilson (2021-22, 2024)
Colorado Rockies (24)
Clint Barmes (2003-10)
Joe Beimel (2009-10)
Jose Contreras (2009)
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